PWS and Obesity, and PWS look-alikes
نویسنده
چکیده
Obesity is a common finding in our general population, the proportion of obese individuals having increased at an alarming rate all over the world in the past 20 years. Compared to growth failure, obesity is rare in a population of individuals with a genetic syndrome. One database for genetic syndromes, Online Mendelian Inheritance in Man, contains 169 matches for obesity and 421 matches for growth failure.
منابع مشابه
Dental Management of Patients with Prader Willi Syndrome
Prader–Willi syndrome (PWS) is a genetic disorder which occurs with a frequency of about one in 10,000–30,000 live newborns. Both males and females, and all races are equally affected. PWS is a complex disorder with multiple disabilities, and the main defect is found in the hypothalamus. Child with PWS at the age between 2 and 3 years becomes constantly hungry and if the diet is not controlled,...
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BACKGROUND Individuals with Prader-Willi syndrome (PWS) have extremely regulated diets to prevent the development of morbid obesity. OBJECTIVE This study evaluated potential deficiencies in macro and micronutrients in a cohort of youth with PWS and compared them to a group of children with non-congenital obesity and to US national recommendations. DESIGN Participants were 32 youth with PWS ...
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As part of a study investigating commonalities between Prader-Willi syndrome (PWS-a genetic imprinting disorder) and early-onset obesity of unknown etiology (EMO) we measured total cerebral and cerebellar volume on volumetric magnetic resonance imaging (MRI) images. Individuals with PWS (N = 16) and EMO (N = 12) had smaller cerebellar volumes than a control group of 15 siblings (p = .02 control...
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OBJECTIVE To compare obsessive-compulsive (OC) symptoms in patients with Prader-Willi syndrome (PWS) and symptoms in a group of patients presenting with "Prader-Willi-like" features but without the genetic abnormalities associated with PWS. METHOD 16 patients aged 4 through 20 years were evaluated in a clinic specializing in the assessment and management of behavioral and food-related problem...
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OBJECTIVES To identify metabolic factors controlling appetite and insulin sensitivity in PWS and assess effects of GH treatment. METHODS We compared amino acids, fatty acids and acylcarnitines in GH-treated and untreated PWS children and obese and lean controls to identify biomarkers associated with ghrelin, peptide YY and markers of insulin sensitivity (adiponectin and HOMA-IR). RESULTS Co...
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